Can calming supplements help with my dog's separation anxiety?

Supplements can smooth the edges of anxiety, making your dog more able to learn and respond to training, but they won't resolve separation anxiety on their own.

What research shows

L-tryptophan may help manage mood-related neurotransmitters, particularly when paired with behaviour training (2). L-tyrosine and taurine are building blocks in neurotransmitter pathways linked to stress responses and focus, and have been included in calming formulations. These nutrients don't sedate your dog or make them sleepy, they support the dog's ability to relax and focus, which can make calm-training more effective.

When to use supplements

• Alongside desensitisation work (practicing short, positive absences)
• For dogs who are too distressed to engage with training initially
• During routine transitions (returning to work after holidays and weekends)
• As part of a multi-layered plan, not a standalone fix

What they can't do

Supplements won't teach your dog that being alone is safe. A dog given calming nutrients but no behaviour support will likely remain anxious - just slightly less panicked. True progress comes from building confidence through structured, gradual exposure to short absences paired with positive associations.

Realistic expectations

Benefits build over weeks, not days. Track specific behaviours and jot down any small improvements you notice. It can be really encouraging to look back at a behaviour diary to see how far you and your dog have come, especially on days when it feels like progress has stalled.

For severe separation anxiety, your vet may recommend behavioural medication alongside supplements and training. Some cases need pharmaceutical support to lower distress enough for learning to occur.

References

1. Sofyan L, Browne W, Dean R. Supplementary tryptophan in reducing anxiety and fear-related behaviour. Vet Evid. 2024;9(4). Available from: https://veterinaryevidence.org/index.php/ve/article/view/686